Rejuran vs Exosome: How to Choose
Choosing between two popular skin boosters can feel confusing when both promise smoother, more hydrated skin. This guide compares Rejuran vs Exosome treatments as offered at DERNA Clinic, so you can discuss the right option with a doctor during your consultation. Both are injectable or device-assisted boosters designed to support skin quality, but they use different active ingredients and delivery methods, and individual results vary depending on skin condition, age, and lifestyle factors.
What They Are
Rejuran is a skin booster containing salmon DNA extract, technically known as polynucleotide, which is intended to support the skin's natural regeneration process. At DERNA Clinic it is available as Healer or HB+ formulations, in 2cc or 4cc volumes, applied by hand injection. There is also an eye-area option for patients concerned with the delicate skin around the eyes.
Exosome treatment, by contrast, uses exosome-based solutions delivered through either MTS, a micro-needling technique, or Potenza, a radiofrequency micro-needling device. It is offered in 5cc quantities. Exosomes are cell-derived particles that are thought to support skin communication and repair processes, though research in this area continues to evolve and results are not guaranteed.
When comparing rejuran vs exosome options, it helps to understand that Rejuran is typically injected directly into the dermis, while Exosome treatments are usually applied topically and driven into the skin using a device, meaning the sensation and downtime can differ between the two.
Who It Suits
Rejuran may suit patients dealing with early signs of aging, uneven texture, or skin that feels thin or dehydrated. Because it is injected, it can also target specific areas of concern such as fine lines or acne scarring. The eye option may appeal to those wanting to address fine lines specifically around the eye area.
Exosome treatments, delivered via MTS or Potenza, may appeal to patients who prefer a device-based approach or who are already considering microneedling or radiofrequency treatments and want to combine them with a booster step. It is sometimes chosen by those looking to support overall skin tone and resilience.
Who Should Avoid It
Neither treatment is appropriate for everyone. Patients with active skin infections, open wounds, or significant inflammation in the treatment area should wait until the skin has healed. Those with known allergies to any component of the product, or a history of keloid scarring, should discuss this openly with the doctor beforehand. Pregnant or breastfeeding patients are generally advised to postpone elective cosmetic injections and device treatments until consulting their physician. Patients on blood thinners or with bleeding disorders should also mention this during consultation, as it may affect suitability and bruising risk.
How the Session Goes
For Rejuran, the doctor typically cleanses the skin, may apply a topical numbing cream, and then performs a series of small injections across the treatment area using a fine needle. The number of injection points depends on the area size and the volume selected.
For Exosome treatment, the process usually begins with cleansing and numbing, followed by either MTS microneedling or Potenza radiofrequency microneedling to create controlled micro-channels in the skin, after which the exosome solution is applied and absorbed. Sessions for either treatment generally take between twenty and forty-five minutes, though exact timing depends on the treatment area and technique used.
Downtime and Recovery
Mild redness, small bumps, or minor bruising at injection points are common after Rejuran and typically settle within a few days. Some patients notice small raised areas immediately after injection that flatten over subsequent days. Makeup can often be applied the following day, though this should be confirmed with the treating doctor.
Exosome treatment via microneedling or Potenza may cause temporary redness similar to a mild sunburn sensation, along with some pinpoint bleeding immediately after the session. This usually resolves within one to three days. Sun protection and gentle skincare are generally recommended for several days following either treatment, and results from both approaches tend to build gradually over subsequent weeks rather than appearing immediately.
Pricing
At DERNA Clinic, Rejuran is priced at 250,000 KRW, while Exosome treatment is priced at 230,000 KRW. These prices reflect the listed treatment and quantity as described above; additional consultation fees or VAT may apply, and final pricing should always be confirmed directly with the clinic before booking, since add-on options such as combining techniques or treating multiple areas can affect the total.
| Feature | Rejuran | Exosome |
|---|---|---|
| Main ingredient | Salmon DNA extract (polynucleotide) | Exosome-based solution |
| Delivery method | Hand injection | MTS or Potenza device |
| Available volume | 2cc or 4cc (plus eye option) | 5cc |
| Price | 250,000 KRW | 230,000 KRW |
Safety
Both treatments carry the general risks associated with injectable or device-based skin procedures, including temporary redness, swelling, bruising, or in rare cases infection if aftercare instructions are not followed. No cosmetic treatment can promise a specific outcome, and results differ from person to person depending on skin type, age, and how the skin responds to treatment. A thorough consultation with one of the clinic's doctors, including a review of medical history and any allergies, is an important step before proceeding with either option. Patients should also disclose any medications, supplements, or prior cosmetic treatments that might interact with the procedure.
Frequently asked questions
Which lasts longer, Rejuran or Exosome?
Duration varies by individual and is influenced by skin condition, lifestyle, and how many sessions are completed, so neither treatment can be said to universally outlast the other.
Can Rejuran and Exosome be combined in one visit?
Some patients discuss combining treatments with their doctor, but suitability depends on skin condition and treatment goals, so this should be assessed during a consultation rather than assumed.
Is one treatment more painful than the other?
Both involve some discomfort, typically minimized with topical numbing; Rejuran involves needle injections while Exosome delivery via microneedling may feel like light scratching or pressure.
How many sessions are typically needed?
The number of sessions depends on individual skin concerns and goals, and this is best determined together with the treating doctor rather than following a fixed schedule.
Do the listed prices include consultation and VAT?
Pricing may vary depending on consultation and VAT, so it is advisable to confirm the total cost directly with DERNA Clinic before scheduling a session.